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Publications using hctsa

This page lists scientific research publications that have used hctsa.

Articles are labeled as follows:

  • πŸ“— = Journal publication.

  • πŸ“™ = Preprint.

  • πŸ’» = Link to GitHub code repository available.

If you have used hctsa in your published work, or we have missed any publications, feel free to reach out by and we'll add it this growing list!


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Our Research πŸ“•

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Methods Papers

The following publications for details of how the highly-comparative approach to time-series analysis has developed since our initial publication in 2013. We:


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Applications Papers

We have used hctsa to:

as well as:

  • Distinguish wake from anesthetized flies.

  • Connect structural brain connectivity to fMRI dynamics (mouse).


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Others' Research πŸ“•

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🧬 Biology


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🧫 Cellular Neuroscience


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🧠 Neuroimaging

Here are some highlights:

In addition to:

  • Predict depth of anesthesia from heart-rate dynamics.

  • Detect associations between brain region dynamics and traits like cognitive ability and substance use.


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πŸ”¬ Medicineβ€”General

Here are some highlights:

in addition to:

  • Predicting hospital length of stay from vital signs

    • Juez–Garcia et al. (2025).

  • Differentiate essential tremor (ET) and tremor-dominant Parkinson's disease (PD)


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🦠 Medicineβ€”Pathology


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πŸ— Engineering

Here are some highlights:

in addition to:

  • Diagnose a spacecraft propulsion system utilizing data provided by the Prognostics and Health Management (PHM) society, as part of the Asia-Pacific PHM conference’s data challenge, 2023.

    • .

  • Identify faults in a large-scale industrial process.


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⛰️ Geoscience


πŸ“— Chaos (2017)arrow-up-right.

  • Connect structural brain connectivity to fMRI dynamics (human).

    • πŸ“— Network Neuroscience (2020)arrow-up-right.

  • Distinguish time-series patterns for data-mining applications.

    • πŸ“— IEEE Trans. Knowl. Data Eng. (2014)arrow-up-right.

  • Classify babies with low blood pH from fetal heart rate time series.

    • πŸ“— 34th Ann. Int. Conf. IEEE EMBC (2012)arrow-up-right.

  • οΏ½ Tian et al., Nature Human Behavior (2025).arrow-up-right

  • Predict age from resting-state MEG from individual brain regions.

    • οΏ½arrow-up-right Stier et al., PNAS (2025).arrow-up-right

  • Estimate brain age in children from EEG.

    • πŸ“— 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (2023)arrow-up-right.

  • Extract gradients from fMRI hctsa time-series features to understand the relationship between schizophrenia and nicotine dependence.

    • πŸ“— Cerebral Cortex (2023)arrow-up-right.

  • Classify endogenous (preictal), interictal, and seizure-like (ictal) activity from local field potentials (LFPs) from layers II/III of the primary somatosensory cortex of young mice (using feature selection methods from an initial pool of hctsa features).

    • πŸ“™ SciTePress (2023)arrow-up-right.

  • Distinguish motor-evoked potentials corresponding to multiple sclerosis.

    • πŸ“— Frontiers in Neuroinformatics (2020)arrow-up-right.

  • HΓ€ring et al. Phenotypical Differentiation of Tremor Using Time Series Feature Extraction and Machine Learning, Movement Disorders (2025)arrow-up-right

  • Predict MS disability progression using time-series features of evoked potential signals

    • πŸ“— Fonteyn et al. International Conference on Machine Learning and Applications (ICMLA). (2025)arrow-up-right.

  • Identify sepsis in very low birth weight (<1.5kg) infants from heart rate signals, identifying heart rate characteristics of reduced variability and transient decelerations.

    • πŸ“™ MedRxiv (2024)arrow-up-right

  • Identify novel heart-rate variability metrics, including RobustSD, to create a parsimonious model for cerebral palsy prediction in preterm neonatal intensive care unit patients.

    • πŸ“— Pediatric Research (2023)arrow-up-right.

  • Predicting post cardiac arrest outcomes.

    • πŸ“— Anaesthesia Critical Care & Pain Medicine (2022)arrow-up-right.

  • Detect falls from wearable sensor data.

    • πŸ“— Scientific Reports (2021)arrow-up-right.

  • Detect falls from wearable sensor data.

    • πŸ“— Biosensors (2021)arrow-up-right.

  • Select features for fetal heart rate analysis using genetic algorithms.

    • πŸ“— Physiological Measurement (2014)arrow-up-right.

  • PhD Thesisarrow-up-right.

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    πŸ“— Leung et al. PLoS Biology (2025).arrow-up-right
    Qian et al., Br J Anaesth (2025).arrow-up-right
    Continuous vital sign monitoring for predicting hospital length of stay: a feasibility study in chronic obstructive pulmonary disease and chronic heart failure patientsarrow-up-right
    πŸ“— Proceedings of the Asia Pacific Conference of the PHM Society (2023)arrow-up-right
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    Reduced the hctsa feature library down to a reduced set of 22 efficiently coded features: catch22.

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    Developed a software package for highly-comparative time-series analysis, hctsa (includes applications to high throughput phenotyping of C. Elegans and Drosophila movement time series).

    πŸ’» .

    πŸ’» .

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    Introduced the feature-based time-series analysis methodology.

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    Showed that the behaviour of thousands of time-series methods on thousands of different time series can be used to organise the interdisciplinary time-series analysis literature.

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    Find dynamical signatures of psychiatric disorders from resting-state fMRI data.

    πŸ“— PLoS Comp. Biol. (2024).

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    Predict individual response to rTMS depression treatment from EEG data.

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    Distinguish meditators from non-meditators from 30s of resting-state EEG data.

    πŸ“— .

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    Identify neurophysiological signatures of cortical micro-architecture.

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    Classify stars from NASA's Kepler Mission.

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    Determine how striatal neuromodulation affects brain dynamics in thalamus and cortex.

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    Uncover the dynamical structure of sleep EEG.

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    Show how gradients of variation in time-series properties of BOLD dynamics vary with physiological variation and structural connectivity in the human neocortex.

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    Distinguish targeted perturbations to mouse fMRI dynamics.

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    πŸ’» .

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    Extract acoustic features from social vocal accommodation in adult marmoset monkeys.

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    Track Drosophila in real time for high-throughput behavioural phenotyping.

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    Detect anger from photoplethysmography (PPG) sensors.

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    Identify and distinguish marmoset vocalisations from audio, using Adaboost feature selection from hctsa features.

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    Discriminate zebra finch songs in different social contexts.

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    Distinguish electromagnetic field exposure from zebrafish locomotion time series.

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    Confirm the role of Β΅ORs in VTA and NAc in acute fentanyl-induced behaviour (positive reinforcement).

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    Assess stress-induced changes in astrocyte calcium dynamics.

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    Assess the stress controllability of neurons from their activity time series.

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    Understand changes in fMRI brain dynamics in patients with epilepsy.

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    Extract EEG markers of cognitive decline.

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    Detect EEG markers of seizure disorders.

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    Capture a distinctive fingerprint of an individual's resting-state fMRI data.

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    Identify methamphetamine users from EEG time series.

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    Compute temporal profile similarity for individual fingerprinting from human fMRI data.

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    Characterise subnetworks of the frontoparietal control network from fMRI recordings.

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    Find time-series properties of motor-evoked potentials that predict multiple sclerosis progression after two years.

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    Detect mild cognitive impairment using single-channel EEG to measure speech-evoked brain responses.

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    Differentiate tremor disorders using massive feature extraction, outperforming the best traditional tremor statistic.

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    Identify physiological features predictive of respiratory outcomes in extremely pre-term infants from bedside monitor data.

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    Discover signatures of fatal neonatal illness from vital signs.

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    Detect falls in elderly people from accelerometer data.

    πŸ“—

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    Prediction of post-cardiac arrest outcomes at discharge from physiological time series recorded on the first day of intensive care.

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    Detect falls of elderly people using wearable sensors.

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    Demonstrate that the suppression of essential tremor is due to a disruption of oscillations in the olivocerebellar loop.

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    Classify heartbeats measured using single-lead ECG.

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    Assess muscles for clinical rehabilitation.

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    Screen for COVID-19 using digital holographic microscopy.

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    Detect COVID-19 from red blood cells using digital holographic microscopy.

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    Identify the biogeographic heterogeneity of mucus, lumen, and feces.

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    Detect keyhole porosity formation during laser irradiation of Ti-6Al-4V substrates.

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    Identify keyhole pores in a laser powder-bed fusion process using acoustic and inline pyrometry time series.

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    Detect false data injection attacks into smart meters.

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    Predict pending loss of power stability from generator response signals.

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    Detect seeded bearing faults on a wind turbine subjected to non-stationary wind speed.

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    Recognise hand gestures.

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    Distinguish energy use behaviours from smart meter data.

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    Non-intrusively monitor load for appliance detection and electrical power saving in buildings.

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    Evaluate asphalt irregularity from smartphone sensors.

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    Detecting earthquakes from seismic recordings.

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    Find temporal patterns for reconstructing surface soil moisture time series.

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    Predict earthquakes (in the following month) from seismic indicators in Bangladesh.

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    Detect earthquakes in Groningen, The Netherlands.

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    πŸ“—arrow-up-right
    Data Mining and Knowledge Discovery 33, 1821 (2019).arrow-up-right
    catch22 Code.arrow-up-right
    πŸ“—arrow-up-right
    Cell Systems 5, 527 (2017).arrow-up-right
    Code (fly)arrow-up-right
    Code (worm)arrow-up-right
    πŸ“—arrow-up-right
    Feature Engineering for Machine Learning and Data Analytics, CRC Press (2018).arrow-up-right
    arrow-up-right
    πŸ“™arrow-up-right
    Preprintarrow-up-right
    πŸ“—arrow-up-right
    J. Roy. Soc. Interface (2013).arrow-up-right
    πŸ“™ medRxiv (2023)arrow-up-right
    Neural Networks (2023)arrow-up-right
    πŸ“— Nature Comms. (2023)arrow-up-right
    πŸ“— Monthly Notices of the Royal Astronomical Society (2022)arrow-up-right
    πŸ“— eLife (2023)arrow-up-right
    πŸ“— Sleep Medicine (2022)arrow-up-right
    πŸ“— eLife (2020)arrow-up-right
    πŸ“— Cerebral Cortex (2020)arrow-up-right
    Codearrow-up-right
    πŸ“™ bioRxiv (2023)arrow-up-right
    πŸ“— eLife (2023)arrow-up-right
    πŸ“— Journal of NeuroEngineering and Rehabilitation (2023)arrow-up-right
    πŸ“— J. Roy. Soc. Interface (2023)arrow-up-right
    πŸ“— PLoS Computational Biology (2021)arrow-up-right
    πŸ“— Sensors (2020)arrow-up-right
    πŸ“— Chaudun et al., Nature (2024).arrow-up-right
    πŸ“— Nature Comms. (2020)arrow-up-right
    πŸ“— Nature Neuroscience (2020)arrow-up-right
    πŸ“— Communications Biology (2024)arrow-up-right
    πŸ“— npj Aging (2024)arrow-up-right
    πŸ“— Brain Communications (2023)arrow-up-right
    πŸ“™ ResearchSquare (2023)arrow-up-right
    πŸ“™ ResearchSquare (2023)arrow-up-right
    πŸ“— Network Neuroscience (2023)arrow-up-right
    πŸ“™ bioRxiv (2023)arrow-up-right
    πŸ“— BMC Neurology (2020)arrow-up-right
    πŸ“— IEEE Transactions on Neural Systems and Rehabilitation Engineering (2019)arrow-up-right
    πŸ“™ MedRxiv (2024)arrow-up-right
    πŸ“™ MedRxiv (2024)arrow-up-right
    πŸ“— npj Digital Medicine (2022)arrow-up-right
    IEEE International Conference on Information and Communication Technology for Sustainable Development (2021).arrow-up-right
    πŸ“— Anaesthesia Critical Care & Pain Medicine (2021)arrow-up-right
    πŸ“— IEEE Access (2021)arrow-up-right
    πŸ“— Nature Comms. (2021)arrow-up-right
    πŸ“— IEEE 42nd International Convention on Information and Communication Technology, Electronics and Microelectronics (MIPRO) (2019)arrow-up-right
    πŸ“— 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (2017)arrow-up-right
    πŸ“— Biomedical Optics Express (2022)arrow-up-right
    πŸ“— Optics Express (2022)arrow-up-right
    πŸ“— PNAS (2021)arrow-up-right
    πŸ“— Additive Manufacturing (2023)arrow-up-right
    πŸ“— Journal of Materials Processing Technology (2022)arrow-up-right
    IEEE Access (2021).arrow-up-right
    πŸ“— IEEE Access (2021)arrow-up-right
    πŸ“— Proceedings of the Seventeenth International Conference on Condition Monitoring and Asset Management (2021)arrow-up-right
    πŸ“— PLoS ONE (2020)arrow-up-right
    πŸ“— Energy and Buildings (2019)arrow-up-right
    πŸ“— Energy and Buildings (2019)arrow-up-right
    πŸ“— International Symposium on Intelligent Data Analysis (2018)arrow-up-right
    πŸ“— Geophysical Prospecting (2023)arrow-up-right
    πŸ“— Journal of Hydrology (2023)arrow-up-right
    πŸ“— IEEE Access (2021)arrow-up-right
    πŸ“— 82nd EAGE Annual Conference & Exhibition Workshop Programme (2020)arrow-up-right